SAMEA14085799 ERS11688930 uncultured Clostridia bacterium This sample represents a Third Party Annotation (TPA) Metagenome-Assembled Genome (MAG) assembled from the metagenomic run SRR5091460 of study SRP094805. EBI Generic Generic.1.0 ERC000047 2023-01-03 2023-01-03 SAMEA14085799 EBI European Bioinformatics Institute 2023-01-03T00:33:46Z 2023-01-03T00:33:46Z public SRR5091460_bin.45_CONCOCT_v1.1_MAG Many fragments with little to no review of assembly other than reporting of standard assembly statistics metaspadesv3.11.1 Default CONCOCT v1.1 EMG broker account, EMBL-EBI 2015-10-01 99.78 CheckM 0.67 Host-associated Human Digestive system China 30.3 120.2 metagenome-assembled genome human gut metagenome human gut metagenome Gut microbiome make contributions to human host, and intestinal dysbiosis is associated with rheumatoid arthritis. Here we firstly demonstrated that the human gut microbiome related to rheumatoid arthritis could be divided into subtyping groups under different human enterotypes, which indicate the associations between rheumatoid arthritis and gut microbiome were diverse. In rheumatoid arthritis-related microbiota, Prevotella could be an indicator of early rheumatoid arthritis patients but insufficient to differentiate RA patients from healthy controls, and Bacteroides coprocola enriched in group 3 and Bacteroides dorei enriched in group 4 were considered to be as indicators of serious rheumatoid arthritis patients. Our findings provide additional evidences supporting that rheumatoid arthritis is a heterogeneous disease. Thus, the study of association between disease and gut microbiome should be conducted under different human gut enterotypes. SAMN06112090 SRR5091460_bin.45_CONCOCT_v1.1_MAG uncultured Clostridia bacterium Illumina HiSeq 2000 multi-marker approach