SAMEA14084379 ERS11687512 uncultured Collinsella sp. This sample represents a Third Party Annotation (TPA) Metagenome-Assembled Genome (MAG) assembled from the metagenomic run ERR414448 of study ERP004605. EBI Generic Generic.1.0 ERC000047 2023-01-03 2023-01-03 SAMEA14084379 EBI European Bioinformatics Institute 2023-01-03T00:33:41Z 2023-01-03T00:33:41Z public ERR414448_bin.20_CONCOCT_v1.1_MAG Many fragments with little to no review of assembly other than reporting of standard assembly statistics spades_v3.11.1 Default CONCOCT v1.1 EMG broker account, EMBL-EBI 2008-01-01 89.74 CheckM 3.61 Host-associated Human Digestive system Spain 40.416634 -3.7037659 metagenome-assembled genome human gut metagenome human gut metagenome The gut microbiota is key to human health and disease. Metagenome-wide association studies (MGWAS) that search for disease markers in the gut microbiota, species identification according to metagenomic linkage groups (MLGs) or metagenomic clusters (MGCs), and metatranscriptomics or metaproteomics studies, all depend on a reference gene catalog, which has only been available for individual cohorts or based on reference genome or protein sequences. Here we report a high-quality integrated reference gene catalog consisting 9,879,896 genes, using 6.4 TB sequencing data derived from 1267 published and unpublished human gut metagenomes from three continents. The catalog represents a comprehensive collection of common and rare species, genes and genetic variants, and suggests individuality in the human gut microbiota. Analyses of a group of Chinese and Danish samples using the catalog revealed country-specific signatures in nutrient and xenobiotic metabolism. Our data suggest that interventions on nutrition, pollution and epidemiology should be tailored to the gut microbiota of a given population or even personalized for an individual. SAMEA2338818 ERR414448_bin.20_CONCOCT_v1.1_MAG uncultured Collinsella sp. Illumina HiSeq 2000 multi-marker approach