SAMEA14083312 ERS11686446 Methanobrevibacter woesei This sample represents a Third Party Annotation (TPA) Metagenome-Assembled Genome (MAG) assembled from the metagenomic run ERR1018268 of study ERP012177. EBI Generic Generic.1.0 ERC000047 2023-01-03 2023-01-03 SAMEA14083312 EBI European Bioinformatics Institute 2023-01-03T00:33:30Z 2023-01-03T00:33:30Z public ERR1018268_bin.70_CONCOCT_v1.1_MAG Many fragments with little to no review of assembly other than reporting of standard assembly statistics metaspadesv3.11.1 Default CONCOCT v1.1 EMG broker account, EMBL-EBI 2012-01-01 100 CheckM 0.0 Host-associated Human Digestive system China 55.676098 12.568337 metagenome-assembled genome human gut metagenome human gut metagenome We performed a metagenome-wide association study on fecal samples from 74 CRC patients and 54 controls from China and validated the results in 16 patients and 24 controls from Denmark. We further validated the biomarkers in two published cohorts from France and Austria. Finally, we employed targeted quantitative PCR (qPCR) assays to evaluate the diagnostic potential of selected biomarkers in an independent Chinese cohort of 47 patients and 109 controls. SAMEA3541552 ERR1018268_bin.70_CONCOCT_v1.1_MAG Methanobrevibacter woesei Illumina HiSeq 2000 multi-marker approach