SAMEA112444859 ERS14555152 uncultured Clostridiaceae bacterium This sample represents a Third Party Annotation (TPA) metagenome-assembled genome assembled from the metagenomic run ERR4405424 of study ERP123227. EBI Generic Generic.1.0 ERC000047 EMG ERR4405424_bin.11_metawrap_v1.3_MAG Many fragments with little to no review of assembly other than reporting of standard assembly statistics metaSPAdes v3.15.3 MaxBin2, MetaBat2, Concoct with default parameter of the metaWRAP pipeline. Bin refinement module used from metaWRAP with default parameters. metawrap v1.3 mouse digestive system EBI-EMG not provided 75.17 CheckM 1.01 feces USA 32.842 -117.258 metagenome-assembled genome mouse gut metagenome digestive tube mouse gut metagenome Chronic viruses such as Human Immunodeficiency Virus or Hepatitis C Virus currently afflict hundreds of millions of people worldwide. Some chronic viruses are able to colonize mucosal surfaces such as the gastrointestinal tract (GI), which act as barrier tissues that allow selective interaction of the host’s mucosal immune system with environmental factors such as microbiota, food antigens or pathogens. Gut mucosal alterations are associated with highly inflammatory conditions and diseases including obesity and autism. Although numerous correlative studies associate specific GI tract microbial species with immune parameters and health of HIV-infected individuals, mechanistic studies establishing a causal relationship between certain components of the microbiota, the anti-viral immune response, host resistance and tolerance to the infection are lacking. Here we propose to combine high- throughput microbiological techniques with immunological approaches in order to gain functional understanding on the impact of the intestinal microbiota in gut health and overall anti-viral immunity in a well-established mouse model of chronic viral infection. By doing so, we will contribute to the basic understanding on how hosts can adapt to life-long coexistence with persistent pathogens and the implications for host health SAMEA7118375 ERR4405424_bin.11_metawrap_v1.3_MAG uncultured Clostridiaceae bacterium Illumina HiSeq 4000 The taxonomy of this Metagenome-Assembled Genome was originally computed with GTDBtk, which assigned the following taxonomic annotation: d__Bacteria;p__Firmicutes;c__Clostridia;o__Eubacteriales;f__Clostridiaceae;g__;s__ multi-marker approach